Conference Day Two

All times in EDT

8:20 am Chairs Opening Comments

8:30 am Infant Development – The First Year Life – Panel

  • Josef Neu Professor, Department of Pediatrics, University of Florida
  • Liza Konnikova Assistant Professor, Yale School of Medicine
  • Laxmi Yervuva Research Leader, Arkansas Childrens Nutrition Center
  • Anders Damholt Head of Clinical Development, Chr. Hansen

Synopsis

  • Where are the most disruptive research progress appearing in the field?
  • What do we know now that we didn’t 12 months ago?
  • Where do we believe the field is hoping to achieve in the next 12 months?
  • How important is the mother and child’s microbiome for the first year of life?

Birth & the Relationship Between Mother, Milk & Infant

9:00 am Milk & the Microbiota

  • Laxmi Yervuva Research Leader, Arkansas Childrens Nutrition Center

Synopsis

  • Understand the important role of human milk on microbiota and infants’ health
  • Impact of neonatal diet on infants metabolic and immune health
  • Human milk: lessons learned from animal model

9:30 am Viewing Mastitis Through a Metagenomic & Metabolomic Lens

  • Ryan Pace Postdoctoral Fellow, University of Idaho

Synopsis

  • How human milk-associated microbiota relate to risk or resilience of mastitis
  • Human milk inflammatory markers as predictors of mastitis
  • How human milk composition is altered in relationship to mastitis or infectious disease

10:00 am Integrated Trajectories of Milk, Nasal, & Gut Microbiome in the First Year of Life Predict Long-term Health Phenotypes

  • Liat Shenhav Independent Research Fellow, The Rockerfellow University

Synopsis

  • Listen to research involving human milk and infant microbiome development
  • Uncover this by understanding longitudinal analysis, microbiome succession and colonization
  • Hear the successful disease prediction that can come with this process

10:30 am MORNING NETWORKING & COFFEE BREAK

11:00 am Greater Than the Sum of its Parts: Considering the Complexity of Human Milk

Synopsis

  • Measuring the compositional variability of human milk
  • Integration of human milk multiomic data
  • Moving beyond reductionist approaches to studying human milk

11:30 am Innovating Infant Nutrition: Modification of the Infant Microbiome Through a Novel Infant Formula Protein Blend

Synopsis

  • Bioactive proteins in breast milk can be utilized in infant formula to create a protein blend with microbiome benefits
  • Nutrition can drive microbiome profiles linked to clinical outcomes to benefit formula fed infants
  • Modification of the microbiome with a novel protein matrix can impact immune development

12:00 pm Lactobacillus Plantarum WJL, a Precibiomic™ Strain Promoting Host Growth by Enhancing Amino Acids Absorption

Synopsis

  • Introducing a new Precibiomic™ strain
  • Describing the mechanism of action resulting in promoting amino acids absorption and growth factors
  • Presenting the preclinical studies on juvenile rodent growth

12:30 pm LUNCH BREAK & NETWORKING OPPORTUNITIES

Pre-term Birth: Diagnosis, Prevention & Health Outcomes

1:30 pm Growth & the Pre-term Infant Microbiome

  • Katherine Stumphf Assistant Professor, The University of Texas Southwestern Medical Center at Dallas

Synopsis

  • Discussing the “typical” microbiome in a pre-term infant, and how it changes in the NICU over time
  • What changes it?
  • What patterns we are seeing so far in our study as infants grow well or grow poorly?

2:00 pm Prediction of Pre-term Birth by use of Non-invasive Innovative Techniques & the Vaginal Microbiome as Predictor for IVF-outcome

Synopsis

  • Innovative techniques and prediction based on a prospective cohort of pregnant women with imminent preterm birth
  • The composition of the vaginal microbiome can be used as predictor for success of ART outcome
  • Low success chance can be used to postpone treatment

2:30 pm Artificial Intelligence & Multi-omics Meets the Pre-term Neonate

  • Josef Neu Professor, Department of Pediatrics, University of Florida

Synopsis

  • Utilization of AI and multi-omics in diagnosis and prevention of intestinal injury in the pre-term neonate
  • Precision nutritional approaches for pre-term neonates and mothers
  • Overall considerations for the present and future of neonatal intensive care with the emergence of AI

3:00 pm Microbial Colonisation in Pre-term Infants; Relation to Intestinal Failure

Synopsis

  • Microbial colonization is critical for immune homeostasis later in life – pre-term infants microbial colonization is disturbed which is associated to intestinal failure and NEC-as well as long term problems in immune homeostasis
  • Listen to recent data and progress in investigating postnatal bacterial and fungal signatures, and intestinal epithelial organoid work to validate their relation to intestinal failure
  • Hear more specifically the role of tryptophan and metabolites that reflect a molecular clue for microbial dysbiosis in the newborn

3:30 pm AFTERNOON BREAK & NETWORKING OPPORTUNITIES

4:00 pm Vaginal Microbiome & Pre-term Birth

  • Anne Dunlap Assistant Professor, Emory University School of Nursing

Synopsis

  • An insight into the Emory University pre-term birth studies

Nutritional Product Development: For the Mother & Infant

4:30 pm From Bench to Shelf: The Process of Developing a Probiotic for Infants

  • Kara Evens Research, International Flavors & Fragrances

Synopsis

  • Addressing the hurdles IFF faced from initial strain discovery, to manufacturing standards, regulatory requirements, and finally market/storage considerations when developing our infant probiotic, Bifidobacterium longum subsp. infantis Bi26
  • Infant products have stricter regulations that include additional safety testing and changes to the manufacturing process to ensure a higher level of safety
  • While characterizing B. infantis Bi26, we found that our strain has different human milk oligosaccharide (HMO) utilization preferences in both isolated and pooled HMO conditions due to genetic differences compared to the type strain

5:00 pm Chr. Hansen’s Research Pipeline

Synopsis

  • Maternal seeding of probiotic bacteria into the infant child: recovery of probiotic bacteria and biomarker
  • Infant seeding of probiotic bacteria into the infant child: recovery of probiotic bacteria and biomarker
  • Clinical evaluation of 16-week supplementation with 5HMO-Mix in healthy-term human infants
  • Probiotics, anticipation stress, and the acute immune response to night shift

5:30 pm Founding Human Infant Bacterial Strains Influence Development of Innate Immunity in Mice

Synopsis

  • Use of bioinformatics and tools for the identification and genetic characterization of key founder strains in human infants
  • Predicting bacterial mechanisms and molecules relevant to both health and disease based on bacterial gene enrichment in the microbiota
  • Applying the murine model to study the role of human infant-sourced founder strains in the context of disease

6:00 pm Chairs Closing Comments & End of Day Two