Conference Day One

Wednesday 29th March 2023

7:30 am
Morning Registration & Refreshments

8:20 am
Chairperson Opening Remarks

8:30 am Panel Discussion: Industry Leaders Update their Highlights from the Last 12 Months in Maternal & Infant Research
Moderated By: Kaile Zagger

  • Kaile Zagger Chief Executive Officer, Infinant Health
  • Nikole Kimes Founder & Chief Executive Officer, Siolta Therapeutics
  • Richard Insel Global Head, Healthy Baby Initiative, World Without Disease Accelerator, Johnson & Johnson Services, Inc
  • Adam Baker Director - Science, Chr. Hansen

Synopsis

  • Hearing what progress has been made by maternal-infant microbiome experts over the last year
  • Outlining a range of industry perspectives across therapeutic and nutritional products
  • Identifying what’s to come in the maternal-infant microbiome field

Assessing the Impact of the Maternal Microbiome on Infant Health to Identify Nutritional & Therapeutic Targets

9:00 am Navigating Mechanisms Behind Immune Training in the Womb: Microbiome or Mother?

  • Nitya Jain Assistant Professor, Harvard Medical School

Synopsis

  • Outlining how immune function in infants is influenced by the maternal immunological experience
  • Navigating how maternal programming of offspring immunity may also take the form of vertically transmitted cells
  • Learning ways in which the maternal microbiome and infection during pregnancy affects maternal microchimeric cells that are acquired by the offspring during gestation

9:30 am Assessing Maternal Diet & Perinatal Stress to Unravel Effects on the Microbiome

  • Mary Kimmel Assistant Professor & Co- Director, Perinatal Psychiatry Program, UNC School of Medicine

Synopsis

  • Delving into data looking at differences in diet (e.g., consumption of dietary fiber) from an assessment of postpartum individuals of their diet over the past year
  • Assessing how these differences associate with psychiatric history
  • Identifying the maternal diet at three time points in relation to microbiome composition

10:00 am Emerging Maternal & Infant Research – the Microbiome Takes Center Stage

Synopsis

  • Appreciating the importance of microbiome science from the moment we are born
  • Outlining the key role of the mother in infant microbiome seeding
  • Deep diving into the mechanisms of bifidaobacteria action in the infant microbiome

10:30 am
Speed Networking & Morning Refreshments

Synopsis

As the maternal-infant microbiome community is reunited, this valuable session will ensure you can

reconnect with your peers in the room to make new and lasting connections.

 

All attendees will have the opportunity to meet and network with their academic and industry colleagues!

11:30 am Navigating the Maternal-Microbiome to Understand Differences in Weight Gain During Pregnancy

Synopsis

  • Discovering contributors to differences in pre-pregnant weight and inappropriate gestational weight gain
  • Examining the contribution of the maternal microbiome to weight gain
  • Outlining the role of the gut microbiome and bidirectional signaling between gut and the brain leading to alterations in weight

Birth, Establishing the Early Infant Microbiome & Links to Later Life

12:00 pm Infant-Microbiome Development: Mom Matters

  • Noel Mueller Associate Professor, Johns Hopkins Bloomberg School of Public Health

Synopsis

  • Addressing the importance of maternal microbiota, including vaginal and fecal microbiota, for the development of the infant microbiota
  • Reviewing the impact of C-section on mother-to-newborn transmission
  • Assessing how we can restore a disrupted infant microbiota

12:30 pm Fireside Discussion: Vaginal vs C-section Delivery

  • Noel Mueller Associate Professor, Johns Hopkins Bloomberg School of Public Health
  • Lydia Mapstone Chief Executive Officer & Co-founder, Booby Biome

Synopsis

  • Analyzing the differences between the microbiomes of C-section/naturally delivered infants
  • Are these differences important and what are the short and long-term impacts?
  • How can these differences be addressed?

1:00 pm
Lunch Break & Networking

2:00 pm Targeting the Vaginal Microbiome to Impact Maternal Health
Virtual

Synopsis

  • Exploring the microbiome in RMMH (Reproductive Medicine and Maternal Health)
  • Understanding Ferring’s approach to the microbiome alliances in the maternal space
  • Sharing results on vaginal studies

2:30 pm Exploring How Early Life Stress & Maternal Condition Impact the Developing Brain & Gut of Offspring

Synopsis

  • Outlining how activation of the mother’s immune system during pregnancy impacts the developing gut, brain, and social behaviour of offspring
  • Determining how caesarean section impacts cellular stress in the brain and gut of offspring in the early postnatal period
  • Identifying impacts in later life

3:00 pm
Afternoon Coffee Break & Networking

Exploring the Infant Microbiome & Links to Disease

3:30 pm Illuminating the Microbiological Signature of Neonatal Leaky Gut to Understand Microbial Targets

  • Bing Ma Assistant Professor, University of Maryland

Synopsis

  • Understanding the role of breastmilk-driven gut microbiome in early intestinal barrier maturation
  • Outlining the neonatal leaky gut and its implications
  • Exploring microbial biomarkers associated with improved neonatal leaky gut

4:00 pm Early Immune System Priming: A Potential Preventative Strategy Against Childhood Leukemia and Other Immune-Mediated Disorders

  • Rachel Gallant Assistant Professor of Pediatric Hematology-Oncology, University of Southern California

Synopsis

  • Exploring the natural history of childhood leukemia and early life risk factors for childhood leukemia, type 1 diabetes, and allergies
  • Navigating the gut microbiome in childhood leukemia compared to that of type 1 diabetes and allergic conditions
  • Modelling prevention strategies

4:30 pm Investigating the Maternal and Infant Microbiome in Populations at High- & Low-risk for Allergic Disease

  • Richard Insel Global Head, Healthy Baby Initiative, World Without Disease Accelerator, Johnson & Johnson Services, Inc
  • Erin Davis Postdoctoral Fellow Paediatric Allergy & Immunology, University of Rochester

Synopsis

  • Discovering how the maternal gut microbiome and metabolome during pregnancy differs in traditional farming and urban communities and the association with differing allergic disease outcomes in infancy
  • Understanding how maternal microbial and metabolic signatures during pregnancy potentially prime the infant immune system towards a tolerogenic phenotype
  • Assessing the developmental trajectory of bifidobacterial species and HMO utilization capacity over the first year of life in farming and urban infants

5:00 pm
Chairperson’s Closing Remarks