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What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

We are a Team of Award-Winning Scientists Creating a World with Healthier Microbiomes Our platform is the result of our team’s combined expertise in genetics, epigenetics, and microbiome research. We utilise deep molecular analysis and next-generation sequencing (NGS) technology to understand the impact of product usage on an individual’s microbiome. Through our efforts, we hope to revolutionise the way in which the industry develops and tests its products to deliver optimal results to those utilising them. Our Mission Sequential is the industry leader in clinical microbiome research and testing offering a comprehensive end-to-end platform designed to bring science-backed solutions to the personal care and pharmaceutical industry. Our mission is to understand the impact of the microbiome on the host (humans) and how the host impacts the microbiome in order to characterise human health fully. We offer an extensive platform to conduct research on personal care products through microbiome testing, and biophysical assessments, and offer full recruitment services for studies. We are keen to publish our findings with our partners to increase the literature within this space. At present our database of over 20,000 human microbiome samples is one of the most sophisticated within the industry and is growing rapidly. Innovation Pioneering the forefront of biological science, we consistently introduce groundbreaking advancements to redefine industry standards. Transparency Our commitment to openness ensures a clear understanding of our human microbiome testing processes and analysis. Reliability We guarantee dependable results, fostering trust in the accuracy of our analyses. Scientific Board of Advisors Our advisors are world leaders in the skin microbiome and have extensive experience in bringing forward solutions for skin concerns Prof. Tom Dawson Senior Principal Investigator at Skin Research Institute of Singapore. Over 30 years experience in biotechnology innovations, and expert in the skin and hair microbiome. Doctor of Philosophy (PhD), Pharmacology at the Univer sity of North Carolina. Dr Kimberly Capone Dr Kimberly Capone is a pioneer and established expert in microbiology and the human microbiome field where she created new business opportunities across multiple brands over 13 years at Johnson & Johnson Consumer, Inc. Areas of concentration included infant and adult skin, vaginal, gut, and oral health. Prof. Phillip Bennett Phillip Bennett is Professor of Obstetrics and Gynaecology and Director of the Institute of Reproductive and Developmental Biology. Professor Bennett has been one of the key pioneers in researching the vaginal microbiome. In particular, to understand and characterise the impact of the vaginal microbiome on preterm labour. Bennett has published over 400 peer-reviewed research articles over his career. Dr Natalya Fox Dr Natalya Fox is a Dermatologist at the NHS - St George's Hospital, London. Previously, Fox did her MBChB at the University of Edinburgh 201 4 and has her Full MRCP UK in Dermatology. Fox is passionate about the skin microbiome and its place in dermatology. Prof. Elena Lurie-Luke A senior R&D, Innovation and Entrepreneurship Executive with extensive technical, strategic business development. Proven leadership experience in both global FMCG and public health sector environments. Prof. Niranjan Nagarajan Associate Director & Senior Group Leader at Genome Institute of Singapore. Expert in computation biology, in particular the study of microbial communities resident on the human skin. Doctor of Philosophy (PhD), Computer Science at Cornell University. Dr Alexander Lezhava Senior Group Leader & Associate Director at Genome Institute of Singapore. Expert in the commercial development of medical diagnostics and clinical-grade molecular assays. Doctor of Philosophy (PhD), Microbiology at Hiroshima University. Please find listed a selection of relevant peer-reviewed publications from our advisors. Wu G, TL Dawson, et al. (2015) Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin. PLOS Genetics 11(11): e1005614. Chng, K., Nagarajan, N., et al. (2016) Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare. Nat Microbiol 1, 16106. Tay, A.S., Nagarajan, N., et al (2018). 1039 Skin microbiome profiles of atopic dermatitis patients segregate into two community composition types that are stable before and after therapy. Journal of Investigative Dermatology. 138. S176. 10.1016/j.jid.2018.03.1051. Ramasamy S., Barnard, E., Dawson, TL, and Huiying Li. (2019). Role of the skin microbiota in acne pathophysiology. British Journal of Dermatology, https://doi.org/10.1111/bjd.18230. Dawson, TL. (2019) Malassezia: The Forbidden Kingdom Opens. Cell Host Microbe https://doi.org/10.1016/j.chom.2019.02.010 Tay, A.S., Nagarajan, N., et al (2020). Atopic dermatitis microbiomes stratify into ecologic dermotypes enabling microbial virulence and disease severity. The Journal of allergy and clinical immunology. 10.1016/j.jaci.2020.09.031. Dawson, TL. (2021) Malassezia: A Skin Commensal Yeast Impacting Both Health and Disease. Front. Cell. Infect. Microbiol., doi.org/10.3389/fcimb.2021.659219 Bissonnette, Robert & FAAD, & Palijan, Ana & Salem, Youssef & Maari, Catherine & Proulx, Etienne & Edjekouane, Lydia & Joly-Chevrier, Maxine & Devis, Andrew & Dashi, Albert & Worsley, Oliver. (2024). 50694 Gut microbiome differences between patients with moderate to severe Chronic Hand Eczema and healthy subjects. Journal of the American Academy of Dermatology. 91. AB224. 10.1016/j.jaad.2024.07.889. Supported By Our Team at Sequential Dr. Oliver Worsley CEO & CO-FOUNDER Oliver is the co-founder and CEO of Sequential. He completed his PhD in molecular genetics as a scholar at the Genome Institute of Singapore from 2014-2018, and has won multiple awards including the P&G Young Entrepreneurship Scheme, presented at the Royal Society in London in 2017; and the top prize at the L’Oréal Innovation Runway 2018. Oliver has previously founded Anya Consulting, a healthcare communications company that has published >150 articles and has produced several technical whitepapers for clients like Fierce Health. Prior, Oliver completed his BSc at Edinburgh University, including six months at Leiden University Medical Centre through the Erasmus Programme. Sibora Peca CLINICAL OPERATIONS LEAD Grace Robinson ASSOCIATE SCIENTIST Shalindri Jayawardene RESEARCH ASSOCIATE Kajal Patel RESEARCH ASSOCIATE Dr. Albert Dashi CHIEF SCIENCE OFFICER & CO-FOUNDER Albert is the co-founder and CSO of Sequential. He completed his PhD in molecular genetics, epigenetics and stem cell research at the National University of Singapore (NUS) and the Genome Institute of Singapore in 2019. In 2014, he received the Singapore International Graduate Award from A*STAR for his PhD research and was also awarded the “Young Investigator” award. He also won the “Young Entrepreneur Scheme” award by P&G for his innovative and business driven ideas. Prior moving to Singapore for his doctor program, Albert obtained his Masters in Biomedical Sciences at University of Bern, Switzerland. Andrew Davis SENIOR BIOINFORMATICIAN Forest Wong SENIOR LAB TECHNICIAN Ashley LaSalle JUNIOR LAB TECHNICIAN Petronille Houdart, PharmD SKINCARE DIRECTOR Petronille is Sequential's lead skincare director, focused on translating the latest in skin science to personalised skincare recommendations. She has over a decade in the industry, working with international brands to lead and consult on R&D, creative projects and brand innovation. Petronille also led her own award-winning dermocosmetic brand, Petronille Dermo Cosmetic, that produced customisable products for men and women. Petronille holds an MSc in Cosmetology Sciences and a professional doctorate in pharmacy (specialising in dermo-pharmacy) from Paris Descartes University. Marya Sheikh-Ahmed SENIOR MARKETING ASSOCIATE Dr. Sija Sajibu RESEARCH ASSOCIATE Melissa Ople ADMINISTRATIVE ASSISTANT Annabelle Schaefer RESEARCH ASSOCIATE Our Labs Sequential has microbiome testing labs in New York City, London and Singapore. Being close to our customers has allowed us to reduce turnaround time, whilst retaining the intellectual property in-house. Proud to Have Worked With

Your Clinical Microbiome Testing Partner A trusted leader in microbiome testing and research for the personal care industry, Sequential provides cutting-edge solutions to elevate product development. Our extensive microbiome research delivers effective and actionable insights, empowering brands to create innovative, science-backed personal care products that meet consumer demands and set new standards in the market. View Services Brochure 20,000+ Microbiome Sample Database 4,000+ Ingredient Database 10,000+ Testing Participants Globally 60+ Industry Partners Who We Are Sequential is a leading provider of clinical microbiome analysis and microbiome testing services, offering a comprehensive end-to-end platform with science-backed solutions tailored for the personal care and pharmaceutical industries. Our team of award-winning scientists is dedicated to understanding the intricate relationship between the microbiome and its human host, exploring how the microbiome impacts human health and how humans, in turn, influence their microbiome. This holistic approach enables us to fully characterise human health and provide actionable insights for product innovation and efficacy. Learn More What We Offer Microbiome Testing A fully customizable microbiome study to test your product's impact in a real-life context. Formulation Support Allow our formulation experts to guide you through the process of creating a product that maintains the biome. Claims & Certification Test your formulation to understand what marketing claims you can attribute to your product. Strategic Partnerships Join us in full end-to-end partnership (testing to collaborating on white papers). Clinical Assessments Understand your product's impact on transepidermal water loss, pH, and elasticity. Study Recruitment Let us recruit candidates and carry out in-lab testing for your study to ensure controlled collection. Our Testing Capabilities Differentiate your brand by leveraging the power of skin microbiome science to deliver innovative, research-backed personal care products. Stand out from competitors with solutions supported by robust clinical research and gold-standard microbiome certification, appealing to customers seeking credible and cutting-edge personal care innovations. Harness the science of the microbiome to build trust, drive customer loyalty, and position your brand as a leader in the personal care industry. Skin Scalp Vaginal Oral What Our Clients Say “Sequential is one of the world’s most innovative Microbiome companies. The resolution at subspecies level, and to perform quantification of key vaginal microbes, in vivo , was exactly what we wanted at Curive Healthcare to know intricately how our product is working to improve women’s health.” - Matthew Line, Chief Marketing Officer at Curive Healthcare Supporting World-Class Clients & Partners Join Our Partners! Microbiome's Impact on Human Health Aromatic Answers: Can the Oral Microbiome Alter How We Perceive Scent and Taste? That’s Fishy: The Powerful Role of Marine Collagen in Wound Healing Unveiling the Microbial Truth: The Unpleasant Reality of Scalp Malodour Read More Articles FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

< Back Sales Associate East Coast of the United States, USA Job Type Full Time Workspace Hybrid About the Role As a Sales Associate at Sequential, you will be essential in building relationships and expanding our reach within the microbiome industry. Your role will involve supporting business development efforts, assisting in sales strategy execution, and helping grow market share for Sequential’s innovative products and services. You will work closely with the Sales Director and team to meet sales goals, develop client relationships, and contribute to Sequential’s mission of advancing microbiome science. This is a fantastic opportunity for an ambitious sales professional to gain hands-on experience and make a tangible impact in a rapidly growing biotech field. Essential Duties and Responsibilities: Sales Support and Development: Assist in the identification and acquisition of new customer accounts, supporting the growth of Sequential’s client base. Client Relationship Building: Cultivate relationships with existing and prospective clients, focusing on understanding their needs and promoting Sequential’s unique offerings. Market Research: Conduct ongoing research to stay informed on industry trends and competitor activity, providing valuable insights for sales strategies. CRM and Data Management: Maintain accurate records in our CRM (HubSpot), tracking interactions, progress, and key performance indicators. Sales Target Achievement: Work towards defined sales goals, contributing to Sequential’s revenue targets and growth ambitions. Collaborative Efforts: Work closely with marketing, product, and operations teams to align efforts and ensure a seamless customer experience. Product Knowledge Development: Stay up-to-date on Sequential’s product offerings and the latest microbiome research to effectively communicate value to clients. Qualifications and Experience: 1-2 years of sales experience, ideally within the biotechnology, cosmetics, or life sciences fields. Familiarity with CRM systems, preferably HubSpot, and the ability to manage data with accuracy. Strong written and verbal communication skills with a passion for client interaction and customer service. Tech-savvy and eager to leverage technology to enhance sales effectiveness. Bachelor's degree in Life Sciences, Business, or a related field preferred; demonstrated interest in microbiome or biotechnology is a plus. Motivated self-starter with a goal-oriented mindset and excellent organizational skills. Ability to work collaboratively and adapt in a dynamic, fast-paced environment. What You Get from Us: A base salary with a commission structure that rewards your hard work and success. Access to our Equity Incentive Plan, allowing you to grow alongside Sequential as we expand. The chance to work with industry experts in one of the fastest-growing sectors within biotechnology. Be part of a company at the forefront of microbiome research, making an impact in the biotechnology and healthcare fields. About the Company Sequential is a global leader in the skin microbiome field, a team of PhD experts in testing products and their effect on the human microbiome (skin, scalp, oral, vulva). An Innovate UK- and Enterprise Singapore-backed company, with labs in London, New York City and Singapore. Awarded the title "Most Significant" Testing Solution in the Industry - (C&T, 2022). To date, Sequential has amassed over 25,000 human skin microbiome samples and corresponding formulations tested in vivo on the skin. With this vast genomic dataset, Sequential are figuring out optimal formulations that could potentially alleviate skin conditions, for example – acne, atopic dermatitis and rosacea. They have been supported by Innovate UK, Enterprise SG, A*STAR (Genome Institute of Singapore). They have raised $4.3MM USD to date from SOSV, Metaplanet, Scrum Ventures, Corundum Systems Biology and are a resident company of JLABS Innovation (in NYC). Apply Now

< Back Head of Growth East Coast of the United States, USA Job Type Full Time Workspace Hybrid About the Role As the Head of Growth for Sequential, you will play a pivotal role in driving the commercial success of our microbiome-focused products and services. Your responsibilities will include marketing, sales, and business development, with a focus on expanding market share, increasing revenue, and creating and managing a high-performing, engaged team. You will be responsible for setting and executing strategic sales plans, managing key customer relationships, tracking team performance through defined KPIs, and collaborating with product, marketing, and operations teams to ensure alignment with Sequential’s growth goals. A strong understanding of the microbiome industry and current market trends is essential to maximize client impact and drive Sequential’s mission forward. Essential Duties and Responsibilities: Develop and execute comprehensive commercialization strategies to achieve ambitious growth objectives. Drive business growth through acquiring new customer accounts, expanding relationships with existing clients, and identifying new market segments. Identify and secure strategic partnerships within the biotechnology, microbiome, cosmetics, and pharmaceutical industries to accelerate market expansion and visibility. Manage and conduct high-level negotiations with senior executives to secure key accounts and establish long-term partnerships. Set ambitious revenue targets and design and implement actionable plans to meet or exceed them, including pricing strategies and go-to-market plans. Team Leadership: Build, lead, and develop a high-performing sales team, fostering a collaborative, results-oriented culture with a focus on accountability and continuous learning. Conduct ongoing market research and competitor analysis to keep strategies competitive and adaptive. Customer Relationship Management and Retention: Strengthen client relationships with a focus on long-term partnerships and retention through exceptional service and communication. Cross-functional Collaboration: Partner with product development, marketing, and operations teams to ensure sales strategies align with company goals and product offerings. Data-Driven Strategy: Use data and analytics to monitor performance, optimize strategies, and inform sales decisions, including regular performance reporting to senior leadership and investors. Remote Work: Primarily remote, with a willingness to meet at our lab in NYC on a monthly basis. Qualifications and Experience: 5+ years of sales or growth leadership experience, preferably in the microbiome, biotechnology, cosmetics, or pharmaceutical fields, though exceptional candidates with less experience will be considered based on performance and potential. Proven track record of exceeding sales targets, driving business development, and managing key client accounts effectively in a startup or scale-up environment. Hands-on experience and proficiency with CRM systems, particularly HubSpot, and data-driven sales methodologies. Strong written and verbal communication skills with the ability to present complex scientific and technical information in a clear and compelling way. Tech-savvy, with a passion for leveraging technology and automation to drive sales success. Demonstrated strategic mindset, with strong analytical skills for tracking performance metrics and adjusting strategies to maximize revenue. MSc/PhD in Life Sciences is preferred; senior sales experience in a commercial environment within Cosmetics, Pharma, or Biotech is advantageous. Exceptional client relationship-building skills with a focus on fostering long-term partnerships. Experience in a Series A/B growth phase or startup environment, with a focus on scaling revenue operations and market presence. Key Attributes for Success: Entrepreneurial mindset with a proactive, results-driven approach. Ability to balance strategic vision with hands-on execution. Adaptability and resilience in a fast-paced, evolving market landscape. Strong leadership, mentoring, and talent development capabilities. What you get from us: Attractive Compensation: A competitive base salary paired with a significant commission structure, rewarding your success and drive. Ownership & Growth: Participate in our Equity Incentive Plan with share options, ensuring you're central to Sequential’s growth and success. Industry-Leading Innovation: Be part of one of the fastest-growing biotech companies in the microbiome industry, where cutting-edge science meets real-world impact every day. About the Company Sequential is a global leader in the skin microbiome field, a team of PhD experts in testing products and their effect on the human microbiome (skin, scalp, oral, vulva). An Innovate UK- and Enterprise Singapore-backed company, with labs in London, New York City and Singapore. Awarded the title "Most Significant" Testing Solution in the Industry - (C&T, 2022). To date, Sequential has amassed over 25,000 human skin microbiome samples and corresponding formulations tested in vivo on the skin. With this vast genomic dataset, Sequential are figuring out optimal formulations that could potentially alleviate skin conditions, for example – acne, atopic dermatitis and rosacea. They have been supported by Innovate UK, Enterprise SG, A*STAR (Genome Institute of Singapore). They have raised $4.3MM USD to date from SOSV, Metaplanet, Scrum Ventures, Corundum Systems Biology and are a resident company of JLABS Innovation (in NYC). Apply Now

< Back Principle Bioinformatician London, United Kingdom Job Type Full Time Workspace Hybrid About the Role Sequential is seeking a Lead Bioinformatician to support our bioinformatics team and data strategy. This pivotal role will involve overseeing the development and implementation of advanced bioinformatics pipelines for skin microbiome analysis, guiding data interpretation for clinical and consumer studies, and contributing to scientific publications and commercial projects. The ideal candidate will bring expertise in microbiome analysis, metagenomics, and machine learning, along with leadership experience in a fast-paced biotech environment. Key Responsibilities: Develop, optimize, and maintain bioinformatics pipelines for skin microbiome data analysis, including amplicon-based and metagenomic pipelines. Oversee data integration and interpretation from high-resolution microbial datasets generated through our 'Smart Probe' technology. Collaborate cross-functionally with R&D, clinical, and commercial teams to drive scientific insights and product development. Drive innovation in bioinformatics tools, statistical models, and data visualization for microbiome analysis. Ensure data quality, reproducibility, and scalability of analytical processes. Contribute to scientific publications and presentations at industry conferences. Maintain awareness of emerging technologies and methodologies in microbiome bioinformatics. Applying best practice of data security and safety Qualifications and expectations: Ph.D. in Bioinformatics, Computational Biology, Microbiology, or a related field. 4+ years of experience in bioinformatics, including leadership roles. Strong expertise in microbiome analysis, metagenomics, and microbial ecology. Experience working with pipelines for network analysis in metagenomic datasets. Experience using the programs QIIME2, Graphpad, Geneious, or ones of equivalent use Proficiency in one or more statistical programming language (R, python, etc) and comfortable working on the command line Use of cloud based platforms (AWS, GCP, Azure, etc) for the handling and storage of large amounts of data Experience with machine learning techniques applied to biological data. application of automation to scale, improve, and standardise large data processes Experience accessing information on NCBI and other similar open source repositories Demonstrated success in leading cross-functional projects and mentoring teams. Strong scientific publication record, and track record of winning grants is a plus. What you get from us: Competitive salary and employee share incentive package. Flexible working arrangements, including remote options. Opportunities for professional development and conference attendance. A collaborative, innovative work environment at the forefront of skin microbiome research. Kindly note that we are not working with recruiters at this time. About the Company Sequential is a global leader in the skin microbiome field, a team of PhD experts in testing products and their effect on the human microbiome (skin, scalp, oral, vulva). An Innovate UK- and Enterprise Singapore-backed company, with labs in London, New York City and Singapore. Awarded the title "Most Significant" Testing Solution in the Industry - (C&T, 2022). To date, Sequential has amassed over 25,000 human skin microbiome samples and corresponding formulations tested in vivo on the skin. With this vast genomic dataset, Sequential are figuring out optimal formulations that could potentially alleviate skin conditions, for example – acne, atopic dermatitis and rosacea. They have been supported by Innovate UK, Enterprise SG, A*STAR (Genome Institute of Singapore). They have raised $4.3MM USD to date from SOSV, Metaplanet, Scrum Ventures, Corundum Systems Biology and are a resident company of JLABS Innovation (in NYC). Apply Now

Sequential in the Press 50694 Gut microbiome differences between patients with moderate to severe Chronic Hand Eczema and healthy subjects Sep-2024 Read Now Is Microbiome Certification even Necessary? 29-Jul-2024 Read Now ‘It’s a really delicate system’: Research on vaginal microbiome shows how little we know about femcare 22-Jan-2024 Read Now Gallinée lance le premier test de santé de la peau et du microbiome à réaliser chez soi 10-Oct-2023 Read Now Lysine-dendrimer: a gentle yet effective acne treatment that maintains skin microbiome, says study 18-Aug-2023 Read Now Acne and ageing: J&J exploring skin health markers via Sequential Skin research tie-up 15-Mar-2023 Read Now Sequential Skin x Johnson & Johnson Collab to Quantify Skin Health 14-Mar-2023 Read Now Understand before purchase: Microbiome testing can help consumers find the right products and eliminate waste 30-Jan-2023 Read Now Sequential Wins New Grant To Propel Skin Microbiome Research 30-Jun-2022 Read Now Sequential Skin launches test to assess ingredient effect on microbiome 22-Mar-2022 Read Now Microbiome start-up Sequential Bio debuts first in-vivo testing for personal care industry 04-Mar-2022 Read Now Sequential Skin Raises $1.6M in Oversubscribed Seed Round 12-Oct-2021 Read Now The skin microbiome brainstorm: Tech, claims and trend-driven NPD 16-Sep-2021 Read Now Skin Sensors Enable Personalized Skin Care 20-Aug-2020 Read Now Sequential Skin: beauty tech’s new approach to genetic analysis and microbiome skincare 09-Mar-2020 Read Now How genetic insights can personalise skin microbiome launches 29-Jul-2019 Read Now New clinical testing to “investigate microbial roots of various skin conditions” 17-Oct-2024 Read Now Losing its meaning? ‘Microbiome-friendly’ terms at risk of misleading consumers – Sequential CEO 29-Jul-2024 Read Now Navigating the realm of intimate care products 17-Jan-2024 Read Now Avec ce test microbiome maison, 10 secondes m'ont suffit pour découvrir les besoins de ma peau 04-Oct-2023 Read Now Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin 3-Aug-2023 Read Now Sequential Announces New Collaboration Agreement to Measure Skin Health for Leading Developer of Personal Care Products 15-Mar-2023 Read Now Sequential Skin partners with Johnson & Johnson on microbiome tests 10-Mar-2023 Read Now Symbiome Partners with Skin Microbiome Testing experts at Sequential to Revolutionize Beauty Industry 26-Jan-2023 Read Now Sequential Skin Nabs $500K UK Grant to Study Skin Microbiome in Atopic Dermatitis 29-Jun-2022 Read Now Demands rising for clinical data on the skin microbiome: Experts 22-Mar-2022 Read Now ‘Maintaining the microbiome’: Biotech startup Sequential Skin debuts in vivo B2B testing service 03-Mar-2022 Read Now Start-up Sequential Skin bags $1.65m of fresh funding 12-Oct-2021 Read Now Singapore Beauty Startup Sequential Skin Uses Science to Help Identify the Best Skincare For You 07-Jan-2021 Read Now Overlooked opportunities? Skin microbiome may play a more important role in personalisation than DNA 13-Aug-2020 Read Now Sequential tool kit prioritises personalisation 15-Jan-2020 Read Now Sequential Launches Industry-First Microbiome Target Panels for Skin Conditions 16-Oct-2024 Read Now From the experts: Top 3 trends in skin microbiome research 20-Jun-2024 Read Now Is Home-Based Skin Microbiome Testing Transforming Beauty and Health Care Industry? 7-Dec-2023 Read Now “Hormone-led changes cause differences to the vaginal ecology that can have an effect on women’s health later in life.” CEO of Sequential 13-Sep-2023 Read Now Sequential and Johnson & Johnson enter partnership to develop new genomic-based skin test 16-Mar-2023 Read Now Sequential Announces New Collaboration Agreement to Quantify Skin Health 15-Mar-2023 Read Now ‘Natural evolution’: Gallinée unveils at-home skin microbiome test kits with Sequential Skin 09-Mar-2023 Read Now Here They Are: Congratulations to the Winners of the 2022 C&T Allēs 29-Sep-2022 Read Now Sequential Skin: Why We Invested 11-Apr-2022 Read Now Sequential Skin Debuts Sequential Bio Testing Solution 09-Mar-2022 Read Now Biotech Start-Up Sequential Skin Raises Funds 10-Dec-2021 Read Now Biotech startup Sequential Skin raises €1.4m – ‘We want to accelerate the future of skin health,’ says CEO 11-Oct-2021 Read Now PODCAST – Holistic view on skin: Sequential Skin on why microbiome testing is crucial to personalised beauty 21-Aug-2020 Read Now Beauté personnalisée: Sequential Skin la Beauty Tech made in Singapore 07-Jul-2020 Read Now GWS 2019 DAY 2 Beauty, Science & Technology: Skin in the Game 25-Nov-2019 Read Now

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What Is a Skin Microbiome Kit? A skin microbiome test kit is a diagnostic tool designed to analyse the microorganisms living on the surface of the skin. These kits assess the diversity and abundance of bacteria, fungi, and other microbes, providing insights into the skin’s microbial ecosystem. The information gathered can help individuals and healthcare providers understand microbial imbalances that might contribute to dermatological conditions or identify strategies to improve skin health. Components of a Skin Microbiome Kit Sampling Materials Swabs: Sterile swabs are used to collect skin samples from specific areas, such as the face, hands, or scalp. Adhesive Strips: In some kits, tape-stripping methods collect deeper microbial samples by gently removing skin cells along with surface microbes. Sample Preservation The collected samples are placed into a vial or test tube containing a stabilising agent to preserve the DNA of microbes until the sample reaches the laboratory. Instructions for Use Clear instructions are included to guide users on how to collect samples correctly to avoid contamination and ensure accurate results. Once the sample arrives at the lab, it undergoes next-generation sequencing (NGS) or polymerase chain reaction (PCR) analysis. These techniques identify microbial DNA and quantify the presence of various microorganisms. (Nafea et al., 2024) Results are typically shared in reports, offering detailed insights into the composition of the user’s skin microbiome and recommendations for skincare or lifestyle adjustments. Applications and Benefits -Personalised skincare: Tailored treatments based on an individual’s skin microbial profile. By identifying specific bacteria or fungi, users can specifically customise their skincare routines, using products designed to promote a healthy microbiome or address specific concerns such as acne or dryness. Companies may also use the microbiome data collected to formulate more effective skincare products in the future. -Identifying dysbiosis: Kits can detect microbial imbalances (dysbiosis), which are associated with conditions such as eczema, acne, and psoriasis. (Borrego-Ruiz & Borrego, 2024) This allows dermatologists to recommend targeted therapies, such as probiotics or prebiotics, to restore balance and improve skin health. (D’Auria et al., 2021) They are also helpful for tracking the effectiveness of treatments over time. -Monitoring the impact of lifestyle changes: The skin microbiome is influenced by environmental factors like humidity, pollution, and UV exposure, as well as lifestyle choices such as diet and stress management. Testing allows users to monitor how these factors affect their microbial health and make adjustments accordingly. (Byrd et al., 2018) -Research purposes: Helping dermatologists and researchers understand the dynamics of skin health better and test the effectiveness of new treatments. This data can drive the development of these new therapies, including microbiome-based interventions, and help identify potential biomarkers for skin disorders. (D’Auria et al., 2021) Scientific Significance The skin microbiome plays a crucial role in maintaining the skin's barrier function and immune responses. Imbalances in these microbial communities are often associated with dermatological conditions, and research continues to explore how restoring balance through topical or oral interventions could improve skin health. Accurate sampling and analysis, however, remain critical challenges for researchers, requiring reproducible methods for reliable results. (D’Auria et al., 2021) Conclusion A skin microbiome kit offers a gateway into understanding the complex ecosystem on our skin. While still emerging as a mainstream tool, these kits are becoming popular in both consumer skincare and clinical research. As more studies focus on the interplay between the skin microbiome and external factors such as diet and environmental exposures, personalised skincare routines may soon become the norm. References Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018). The human skin microbiome. Nature Reviews Microbiology, 16(3), 143-155. https://doi.org/10.1038/nrmicro.2017.157 Borrego-Ruiz, A., & Borrego, J. J. (2024). Microbial Dysbiosis in the Skin Microbiome and Its Psychological Consequences. Microorganisms, 12(9), 1908. https://doi.org/10.3390/microorganisms12091908 D'Auria, E., Acunzo, M., et al. (2021). A journey on the skin microbiome: Pitfalls and opportunities. International Journal of Molecular Sciences, 22(18), 9846. https://doi.org/10.3390/ijms22189846 Nafea, A. M., Wang, Y., Wang, D., Salama, A. M., Aziz, M. A., Xu, S., & Tong, Y. (2024). Application of next-generation sequencing to identify different pathogens. Frontiers in Microbiology, 14. https://doi.org/10.3389/fmicb.2023.1329330

How Do I Test My Microbiome? The microbiome refers to the collection of trillions of microorganisms, such as bacteria, fungi, and viruses, that live in and on your body, particularly in your gut. (Lloyd-Price, Abu-Ali & Huttenhower, 2016) These microbes are vital components in maintaining our health by aiding digestion, regulating the immune system, and even influencing mood and overall brain function. Given the growing interest in the microbiome's impact on overall well-being, testing the microbiome has broadened its appeal among people. Here's an overview of the process, why it's important, and what the results could reveal. Types of Microbiome Tests Skin tests: Skin microbiome samples are typically collected using non-invasive methods, such as swabs, tape strips, or skin scrapings. A swab is gently rubbed over the surface of the skin to capture microbial communities from different body areas, depending on the research or diagnostic needs. These samples are then sent to a lab for DNA sequencing to identify and quantify the microbial species present (Grice & Segre, 2011). This approach allows for a deeper understanding of how the skin's microbial balance impacts health conditions like acne, eczema, and skin infections. Saliva tests: Saliva microbiome testing is a non-invasive approach to assess the bacterial communities in the mouth, offering insights into oral and overall health. Through next-generation sequencing, saliva samples can reveal significant shifts in microbial composition, serving as early biomarkers for health conditions. For example, Aas et al. (2005) demonstrated that saliva microbiome testing could reveal distinct bacterial profiles associated with oral diseases, suggesting its importance in both oral and systemic health management. Stool tests: Stool microbiome testing evaluates the gut’s microbial composition by analysing bacteria, viruses, and fungi in stool samples. This non-invasive test helps identify microbial imbalances (dysbiosis) linked to conditions like irritable bowel syndrome, inflammatory bowel disease, and metabolic disorders. By using next-generation sequencing, it reveals the diversity and abundance of gut microbes, which can inform insights into digestive, immune, and even mental health. Zhernakova et al. (2016) highlighted its potential in detecting gut-related health issues and promoting personalised healthcare strategies. Comprehensive clinical tests: In some cases, healthcare providers may recommend a more comprehensive testing that goes beyond the standard saliva and stool samples which include blood tests or even tissue biopsies; particularly when chronic conditions are present. These approaches can hold valuable information regarding systemic infections or localised imbalances in microbiota, which can significantly aid in the management of diseases such as inflammatory bowel disease and even cancer. (Schulfer & Blaser, 2015) Conclusion By testing our microbiome, we dive into important insights of our overall health by identifying imbalances in microbial communities, known as dysbiosis, which are interlinked to various health conditions. Understanding our microbiome composition allows for customised dietary and lifestyle adjustments to restore balance, as specific gut bacteria are essential for digestion, immune function, and mood regulation. (Zhernakova et al., 2016; Young, 2017) Advancements in microbiome research show that testing can aid in managing chronic diseases by guiding personalised treatment and dietary plans based on an individual's microbial profile, improving clinical outcomes and overall well-being (Lloyd-Price et al., 2016; Hu et al., 2021). Regular testing can optimise health, particularly concerning the gut-brain axis and metabolic health. References Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005). Defining the normal bacterial flora of the oral cavity. Journal of Clinical Microbiology, 43(11), 5721-5732. https://doi.org/10.1128/JCM.43.11.5721-5732.2005 Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016). The healthy human microbiome. Genome Medicine, 8(51), 1-11. https://doi.org/10.1186/s13073-016-0307-y Schulfer, A., & Blaser, M. J. (2015). Risks of antibiotic exposures early in life on the developing microbiome. PLoS Pathogens, 11(7), e1004903. https://doi.org/10.1371/journal.ppat.1004903 Zhernakova, A., et al. (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 352(6285), 565-569. https://doi.org/10.1126/science.aad3369

How do I Rebuild my Skin Microbiome? Our skin, as we know to be the body's largest organ, hosts a plethora of microorganisms. An elaborate ecosystem of bacteria, fungi, and viruses that live on the skin and maintain its optimal health, making up the skin microbiome (Smythe & Wilkinson, 2023). These microorganisms serve as a protective barrier against harmful pathogens, aid in immune system regulation, and play a vital role in various skin functions. However, factors such as harsh skincare products, poor diet, and environmental stressors can disrupt the balance, leading to acne, eczema, and other skin disorders (Wallen-Russell, 2019). Restoring the skin microbiome involves a complex and multifaceted approach that includes lifestyle changes, targeted skincare practices, and sometimes dietary adjustments. Understanding the Skin Microbiome The microbiome varies depending on the region of the skin, with different areas hosting distinct microbial communities. Fournière et al. (2020) examine how Staphylococcus epidermidis and Cutibacterium acnes, key skin microbiota components, vary across different skin environments. For instance, Staphylococcus species are mainly in moist areas like axillary and popliteal creases, while Cutibacterium species are found in sebaceous areas such as the face and back. An ideal and healthy skin microbiome is diverse, and resilient, capable of adapting to changes and defending against adversaries. Steps to Restore the Skin Microbiome 1. Use Less & Gentle Skincare Products: Using lesser products would simplify one’s skincare routine, making it easier to stay consistent and therefore allow the skin to adjust and benefit from the active ingredients. Hwang et al. (2021) further suggests that in order to restore the skin microbiome, one should actively choose products with essential ingredients which are natural, soothing and non-disruptive to the skin's natural barrier. 2. Incorporate Probiotics, Prebiotics and Postbiotics: Just as the gut microbiome benefits from probiotics, so does the skin. Probiotic skincare adds beneficial bacteria to restore skin balance, while prebiotics nourish existing good bacteria to boost their growth. Common probiotics include Lactobacillus and Bifidobacteria, found in drinks, powders, tablets, and fermented dairy products (Gowda, et al. 2024). 3. Protect Your Skin from Environmental Stressors: Limit exposure to environmental pollutants and the sun, which can damage the skin barrier and disrupt the microbiome (Wang et al., 2021). Using protective measures like sunscreen, wearing protective clothing, and cleansing your skin regularly can help maintain the integrity of the skin barrier and support a balanced microbiome. 4. Moisturise Regularly: Keeping the skin well-hydrated is crucial for maintaining a healthy microbiome. Dry skin can compromise the skin barrier, making it easier for harmful bacteria to invade. Use a moisturiser that contains ingredients like ceramides, which help to strengthen the skin barrier, and hyaluronic acid to retain moisture. (Spada & Greive, 2018) 5. Pay Attention to Diet: A diet rich in fruits, vegetables, and whole grains supports skin microbiome health with essential vitamins, minerals, and antioxidants. Omega-3 fatty acids, found in fish and flaxseeds, are particularly beneficial as they have anti-inflammatory properties that can help maintain a balanced skin microbiome. (Costantini, Molinari & Merendino, 2017) Conclusion Restoring the skin microbiome is an ongoing process that demands consistent effort and dedication. By understanding the skin microbiome and incorporating strategies to support its health, you can significantly enhance your skin's ability to protect against environmental stressors and lower the risk of skin disorders. References Smythe, P., & Wilkinson, H. N. (2023). The skin microbiome: Current landscape and future opportunities. International Journal of Molecular Sciences, 24(4), 3950. https://doi.org/10.3390/ijms24043950 Wallen-Russell, C. (2019). The impact of skin care products on skin chemistry and microbiome dynamics. BMC Biology, 17(1), 47. https://doi.org/10.1186/s12915-019-0660-6 Fournière, M., Latire, T., Souak, D., Feuilloley, M. G. J., & Bedoux, G. (2020). Staphylococcus epidermidis and Cutibacterium acnes: Two major sentinels of skin microbiota and the influence of cosmetics. Microorganisms, 8(11), 1752. https://doi.org/10.3390/microorganisms8111752 Hwang, B. K., Lee, S., Myoung, J., Hwang, S. J., Lim, J. M., Jeong, E. T., Park, S. G., & Youn, S. H. (2021). Effect of the skincare product on facial skin microbial structure and biophysical parameters: A pilot study. MicrobiologyOpen, 10(5), e1236. https://doi.org/10.1002/mbo3.1236 Gowda, V., Sarkar, R., Verma, D., & Das, A. (2024). Probiotics in Dermatology: An Evidence-based Approach. Indian dermatology online journal, 15(4), 571–583. https://doi.org/10.4103/idoj.idoj_614_23 Wang, L., Xu, Y. N., Chu, C. C., Jing, Z., Chen, Y., Zhang, J., Pu, M., Mi, T., Du, Y., Liang, Z., Doraiswamy, C., Zeng, T., Wu, J., & Chen, L. (2021). Facial Skin Microbiota-Mediated Host Response to Pollution Stress Revealed by Microbiome Networks of Individual. mSystems, 6(4), e0031921. https://doi.org/10.1128/mSystems.00319-21 Spada, F., Barnes, T. M., & Greive, K. A. (2018). Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems. Clinical, cosmetic and investigational dermatology, 11, 491–497. https://doi.org/10.2147/CCID.S177697 Costantini, L., Molinari, R., Farinon, B., & Merendino, N. (2017). Impact of Omega-3 Fatty Acids on the Gut Microbiota. International journal of molecular sciences, 18(12), 2645. https://doi.org/10.3390/ijms18122645