CONFERENCE DAY ONE
THURSDAY, MAY 23 2019

7.30 Registration & Morning Coffee

8.20 Chairperson Opening Remarks

Demonstrating Causality of Disease Induced by Infant Gut Dysbiosis

Introduction and Purpose:
Directed characterization of microbes in the infant microbiome has been central to understanding the functionality of microbes in both healthy and dysbiotic conditions. Whilst research has focused heavily on finding associations between the early-life gut microbiome and disease onset, the causality of these associations is less known. This theme will showcase new research demonstrating infant host-microbe interactions and causal pathways of the infant gut microbiome.

8.30 

Current & Future Directions of the Maternal-Infant Microbiome & the First 1000 Days

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Speaker TBC
Janssen Pharmaceutical Companies of Johnson & Johnson

9.00 

Celiac Disease & Autism as Models to Show Causality Between Microbiome Composition/Function & Onset of Chronic Inflammatory Diseases (CID)

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Alessio Fasano
Professor & Director Mucosal Immunology & Biology Research Center
Massachusetts General Hospital

9.30 

Healthy Infants Harbour Intestinal Bacteria that Protect Against Food Allergy

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Cathryn Nagler
Bunning Food Allergy Professor
University of Chicago

10.00 

Microbial Influence of Early-Life Immune System Development

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Nitya Jain
Principal Investigator
Harvard Medical School

Defining Tools that Facilitate Microbial Characterization & Pre-Clinical Modelling to Improve Understanding of the Maternal-Infant Microbiome & Select Product Candidates for Further Development

Introduction and Purpose:
It has been difficult to fully characterize the dynamic nature of the maternal and infant microbiome, as well as to simulate in vivo conditions and interactions in the pre-clinical setting. As conventional preclinical tools are not entirely applicable for demonstrating host-microbe interactions, this theme will focus on tools being used to further our understanding of the infant gut microbiome and test product candidates.

10.30 

Baby-SHIME® Technology Platform: A Step by Step Approach for Pre-Clinical Product Testing on the Infant Gut Microbiome

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Aurélien Baudot
International Business Developer
ProDigest

10.40 Speed Networking & Morning Refreshments

11.40 

Using Loop Genomics LoopSeqTM Single-Molecule Long-Read Sequencing to Characterize the Maternal & Infant Microbiome

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Tuval Ben-Yehezkel
CEO
Loop Genomics

Understanding What ‘Good’ Looks Like - Examining the Gut Microbiome of Breast Fed Infants as a Reference Point

Introduction and Purpose:
The benefits of breast feeding are well established. However, questions remain around the influence of maternal diet on breast milk and how this shapes the infant microbiome and disease susceptibility. This theme will explore research focusing on what a ‘good’ infant microbiome looks like and how this can be used as a reference point to establish causality between microbial dysbiosis and disease.

11.50 

Milk & Microbes in the CHILD Cohort: How Breastfeeding and Human Milk Shape the Infant Gut Microbiota and Influence Health Trajectories

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Meghan Azad
Assistant Professor, Pediatrics & Child Health
University of Manitoba

Key Considerations for Study Design Investigating the Maternal-Infant Microbiome on Birth & Infant Health Outcomes

12.20 

Lessons from Longitudinal Studies of the Developing Gut Microbiome

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Joseph Petrosino
CEO
Diversigen

12.50 Lunch & Networking

13.50

Why Neonatal and Pediatric Clinical Trials Fall Short of Expectations

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Devon Kuehn
CMO
Paidion Research, Inc.

14.00

Panel Discussion: Focusing on the Broader Challenges of Developing a Study Protocol

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Panelists:

Meghan Azad
Assistant Professor, Pediatrics & Child Health
University of Manitoba

Ben Callahan
Assistant Professor
NC State University

Nikole Kimes
President, CSO & Co-Founder
Siolta Therapeutics

Exploring the Impact of the Maternal Microbiome on Pregnancy & Infant Health Outcomes

Introduction and Purpose:
Research has demonstrated associations between changes in the maternal microbiome throughout pregnancy with birth and infant health outcomes. However, the use of various methodological approaches towards measuring the impact of the maternal microbiome have resulted in incomparable findings. This session aims to explore studies focusing on understanding the role of the maternal microbiome during pregnancy, in preterm birth outcomes and in C-section birth.

14.30

Composition of the Vaginal Microbiome is Predictive of Preterm Birth in Some Populations of Women

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Ben Callahan
Assistant Professor
NC State University

15.00

Exploring Species and Strain Ecology of the Vaginal Microbiome During Pregnancy and Postpartum

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Ryan Pace
Post-Doctoral Associate, Aagaard Lab
Baylor College of Medicine

15.30

Restoration of Vaginal Exposure After C-Section Normalizes Body Weight

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Keith Martinez
Post-Doctoral Fellow, Dominguez-Bello Lab
Rutgers University

16.00 Afternoon Refreshments & Networking

Mastermind Session: Establishing Gold Standards for Study Design Investigating Live Biotherapeutics in Specific Maternal & Infant Populations

Introduction and Purpose:
This session will facilitate in-depth discussion amongst participants in an informal setting. After splitting into groups, participants will have the opportunity to discuss the study design, data and data analysis considerations needed for well-designed studies that demonstrate the safety and efficacy of microbiome-based products, in specific maternal and infant populations.

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17.10 Chairperson Closing Remarks

17.20 Close of Conference Day One