TIMES SHOWN IN EDT*

8:20 am Chair’s Opening Remarks

  • Camilia Martin Associate Professor of Pediatrics, Harvard Medical School

A Maternal Focus: Nutrition, In Utero Development & Environmental Factors

8:30 am Microbiome Reflections of Pregnancy: Prediction of Maternal and Infant Emotional Regulation

  • Mary Claire Kimmel Assistant Professor & Co-Director Perinatal Psychiatry Program, UNC School of Medicine

Synopsis

• Discussing the role of the vagus in maternal and infant emotional regulation
• Contrasting microbial composition of individuals based on sleep, diet, exercise, and self-reported mood symptom profiles during pregnancy
• Investigating how maternal profiles predict infant stress regulation

8:55 am Maternal Gut Health: The Impacts of Stress On the Maternal/Infant Dyad

Synopsis

• Highlighting the ‘normal’ maternal microbiome
• Contrasting the sequalae of stress in pregnancy on the mother’s microbiome and on infant development
• Addressing the mechanism of action for stress on gut permeability

9:20 am How Did That Get There? The In-Utero Intestine and Unique Metabolomic Presence

  • Liza Konnikova Assistant Professor, Yale University School of Medicine

Synopsis

• Sharing breakthrough research on the appearance of fetal and neonatal metabolites in the small and large intestine, indicative of maternal transfer or bacterial production
• Exploring current conclusions and alignment in the surrounding literature
• Extrapolating future research and meaning for preventative and curative treatments

9:45 am Joint Q&A and Discussion Panel

10:00 am Things to Consider as You Transverse from Discovery to Product Development

Synopsis

  • Characterization is imperative

 

  • The sooner you can pinpoint mechanism of action- the better!

 

  • Target Product Profile (TPP) is essential to the development program

10:10 am Morning Coffee Break

10:30 am Speed Networking

Synopsis

Return to your seat with a hot cuppa and tune in to our interactive and quick-fire networking sessions! Make sure to click ‘connect’ to exchange business cards

The Vaginal Microbiome

11:00 am The Vaginal Microbiome and Metabolome in Spontaneous Preterm Birth

  • Tal Korem Assistant Professor, Department of Systems Biology, Columbia University

Synopsis

• Understanding the vaginal metabolome and how it informs our understanding of microbiome community state types
• Combining the metabolome and microbiome to gain mechanistic insights into the potential microbial involvement in prematurity
• Advancing towards a microbiome-based early risk prediction of prematurity.

11:25 am Precision Medicine Strategies Using NGS and AI in Women’s Health

Synopsis

• Exploring precision infectious disease diagnostics in the context of vaginal health and disease
• Developing and optimizing novel diagnostic tools incorporating NGS and AI to define dysbiosis, infection, and antimicrobial resistance profiles
• Understanding the role of NGS in vaginal microbiome profiling and recurrent urinary tract infections to support and enhance precision diagnostics and therapeutics

11:50 am Precision Vaginome Editing: The Use of Specific Endolysins for the Treatment of Bacterial Vaginosis

Synopsis

• Exploring why there is currently no treatment with satisfactory effectiveness for recurring bacterial vaginosis
• Discovering how PhagoMed has applied synthetic biology to develop a biofilm-breaking, targeted antimicrobial based on phage endolysin fragments
• Discussing how the same approach can be used for many other diseases with a single bacterial species at the root

12:15 pm Midday Q&A and Discussion Panel

12:30 pm Lunch & Open Networking Chat Rooms

Birth: The Infant Microbiome – The Relationship Between Mother, Milk & Infant

1:30 pm Panel: Determining Ideal Breastmilk Composition: What is the Gold Standard of Gold Standards

  • Fernanda Rosa Postdoctoral Researcher, University of Arkansas for Medical Sciences
  • David Sela Associate Professor, University of Massachusetts
  • Andrew A. Bremer Chief, Pediatric Growth & Nutrition Branch, NICHD/NIH
  • Camilia Martin Associate Professor of Pediatrics, Harvard Medical School
  • Christopher Stewart Research Fellow and Group Leader, Newcastle University

2:10 pm Breast Milk and Gut Microbiome in Term and Preterm Infants

Synopsis

• Discussing how the development of gut microbiome in term infants is driven by breast milk
• Analysing how this compares with unpublished preterm infant data (currently being analysed)
• Diving into how human milk oligosaccharides and preterm infant gut microbiome are associated with the onset of necrotising enterocolitis

2:35 pm Human Milk Composition: Informing the Maternal-Infant Interface and Molecular Pathways in Preterm Infant Health and Disease

  • Camilia Martin Associate Professor of Pediatrics, Harvard Medical School

Synopsis

• Identifying determinants and demonstrating variation in human milk composition and its impact in infant health outcomes
• Discussing human lipid biology as an example of maternal-infant immunonutrition
• Proposing nutritional strategies to promote health and reduce morbidities in preterm infants

3:00 pm Disruptive Technologies that Enable New Ingredients in Support of Infant Health & Well-being

Synopsis

  • Consumer interest in the gut microbiome that includes prebiotics, probiotics and postbiotics is growing.
  • While bovine lactoferrin and human milk oligosaccharides are currently used in infant food applications, new technologies that deliver 2-O-Fucosyllactose (2-FL) and recombinant human lactoferrin (hLF) present bigger opportunities and in some cases potentially benefits that may be different from those currently present in the marketplace.
  • Innovations in postbiotics and overall health present future new opportunities in the infant, children and adult in food, beverages and supplements. Butyrate is a well-known short-chain fatty acid that supports gut health. N-(1-carbamoyl-2-phenyl-ethyl) butyramide is a butyric acid releaser with a growing body of science that supports its potential role in infant health.
  • This presentation will provide an overview of three new ingredients applicable to infant health and beyond.

3:25 pm Infant Feeding Practices and the Nasal Microbiome: New Findings From the CHILD Cohort Study

  • Meghan Azad Associate Professor (Pediatrics and Child Health) , University of Manitoba

Synopsis

• Understanding how infant feeding practices (e.g. formula, nursing at the

breast, pumped breast milk) shape the developing nasal microbiome

• Exploring connections between breast milk and nasal microbiomes in

breastfed infants

• Discussing the role of nasal microbes in infant health

3:50 pm Afternoon Q&A and Panel

4:10 pm Afternoon Coffee Break

4:25 pm Understanding the Impact of Human Milk on the Metabolome and Microbiome Using Animal Models

  • Fernanda Rosa Postdoctoral Researcher, University of Arkansas for Medical Sciences

Synopsis

• Drawing direct implications of human milk oligosaccharides alone and in combination with microbiota on the gastrointestinal tract development and immune response using germ-free mice model.
• Looking at the impact of human milk on the circulatory metabolome and gut regions metabolite profile in a neonatal porcine model
• Speculating that possible microbial metabolites may be impacted by diet/host microbiota interactions

4:50 pm Human Milk Non-Protein Nitrogen Influences Microbiome Function Within the Infant Gut

  • David Sela Associate Professor, University of Massachusetts

Synopsis

  • Addressing the links between nitrogen and carbohydrate metabolism within

the infant gut microbiome

  • Explaining the mechanism of action for non-protein nitrogen utilization by gut

microbiota

  • Describing the effects of secreted metabolites within the infant gut

microbiome

5:15 pm Wrap up Q&A and Panel

  • David Sela Associate Professor, University of Massachusetts
  • Fernanda Rosa Postdoctoral Researcher, University of Arkansas for Medical Sciences

5:25 pm Chair’s Closing remarks

  • Camilia Martin Associate Professor of Pediatrics, Harvard Medical School